Bone Void Fillers Market

Bone Void Fillers Market Size and Share:

The global bone void fillers market size reached USD 3.7 Billion in 2024. Looking forward, IMARC Group expects the market to reach USD 6.2 Billion by 2033, exhibiting a growth rate (CAGR) of 5.47% during 2025-2033. North America currently dominates the market, holding a market share of over 39.8% in 2024. This can be credited to the region's well-developed healthcare systems, widespread use of cutting-edge medical advancements, and an increasing need for services fueled by a rapidly aging population.

The rising cases of bone disorders, such as osteoporosis, osteoarthritis, and fractures, are some major factors propelling the bone void fillers market growth. Additionally, changes in lifestyle, aged population, and increased cases of accidents and sports injuries are responsible for the high demand for bone repair remedies, including bone void fillers. For example, according to industry reports, some 400,000 ACL reconstructions are carried out annually in the United States. The growing demand for advanced orthopedic surgical solutions has made bone void fillers an essential component in such procedures. These fillers support new bone growth, help maintain structural integrity in affected areas of the body, and promote faster recovery. Technological advancements in biomaterials, including bioactive and synthetic fillers, further enhance product efficacy and safety, driving their adoption across healthcare facilities globally.

The United States is a critical player in the global bone void fillers market, driven by its advanced healthcare system, extensive R&D capabilities, and high adoption of innovative medical technologies. US-based companies lead the development of cutting-edge fillers, including bioactive and synthetic materials, designed to enhance bone regeneration, improve surgical outcomes, and reduce recovery time. A growing geriatric population, coupled with increasing rates of osteoporosis, fractures, and orthopedic surgeries, continues to drive domestic demand. For instance, recent industry reports states that 34% of 520 adults undergoing surgery for adult spinal deformity (ASD) at one of 13 US and Canadian centers also had severe hip osteoarthritis (OA), affecting spinal alignment and function. Patients with severe bilateral hip OA, averaging 68 years old, showed poorer outcomes. These findings highlight the importance of thorough preoperative evaluations and personalized care for this complex group. Substantial investments in clinical trials and regulatory compliance foster the introduction of novel products. Moreover, strategic collaborations among manufacturers, hospitals, and research institutions further solidify the US's position as a global leader, supporting technological advancements and ensuring market growth.

Bone Void Fillers Market Trends:

The Rising Prevalence of Orthopedic Conditions

Bone void fillers find extensive applications in the treatment of orthopedic conditions. These are widely applied to fill up bone defects, which are created by tumors, infections, or degenerative diseases. According to research, there existed 494 million cases of different musculoskeletal diseases during the year 2020. Over 1990, the population cases increased from 221 million by 123.4%. Between the years 2020 and 2050, the cases concerning different musculoskeletal diseases is projected to have an increase rate of 115% reaching to approximately 1060 million. Bone void fillers also act as a scaffold for new bone formation, which aids in healing and restoring the strength of the bone. They are also used in bone infections, such as osteomyelitis, to fill defects and provide localized antibiotic therapy, thus effectively eradicating the disease and promoting bone healing. Apart from this, bone void fillers provide structural support and support the regeneration of damaged tissues due to conditions like osteoporosis and osteoarthritis. They are also applied in large scale in spinal fusion surgeries for providing stability by fusing more than two vertebrae.

The Increasing Number of Traumatic Surgeries

Bone void fillers are widely used in trauma surgery, when the defects and gaps of the bone are created due to severe injuries. They have structural support so that it enables healing and helps in restoring the integrity of the bone. An astonishing number of 310 million major procedures are performed globally every year with between 40 to 50 million in the United States, and 20 million in Europe, according to data from the National Institutes of Health. Predictions are such that 5–15% of these patients will be readmitted within 30 days while 1–4% will expire, and as many as 15% of them will undergo severe postoperative morbidity. Besides this, bone void fillers are applied in open fractures to fill the defect and cover the exposed bone, thus creating a barrier against infection. They can also be impregnated with antibiotics, thus preventing and treating infections in the traumatic wound. Besides this, bone void fillers are widely used in complex traumatic surgeries involving joints to facilitate the reconstruction and restoration of damaged joint surfaces. They are also used in combination with metal implants for enhancing stability in the implant. This is thus to provide additional support during the healing process in traumatized surgeries.

Significant Technological Advancements

The use of advanced materials as bone void fillers, such as bioactive ceramics, bioresorbable polymers, and composite materials, which mimic the natural structure and properties of bone, thus supporting regeneration and promoting healing, is favoring the market growth. In addition, the recent development of biologically active fillers that can enhance osteogenic potential by promoting cell proliferation, differentiation, and angiogenesis is positively influencing the market growth. Besides, three-dimensional (3D) printing in the form of patient-specific fillers to make perfect fit of the filler into the defect site is a forceful measure boosting the growth in the market. The addition of injectable bone void fillers, which is used as scaffold for the bone and will naturally be absorbed in case of proper growth of bone as a replacement in due course, is helping boost the growth. The creation of void fillers that elute antibiotics to lower the risk of bone infections during orthopaedic surgeries is also receiving more traction lately. For example, in May 2022, BONESUPPORT AB's antibiotic-eluting medicines, which have demonstrated great potential in clinical studies, were approved by the regulatory body.

Bone Void Fillers Industry Segmentation:

IMARC Group provides an analysis of the key trends in each segment of the global bone void fillers market, along with forecast at the global, regional, and country levels from 2025-2033. The market has been categorized based on type, form, application, and end user.

Analysis by Type:

• Demineralized Bone Matrix
• Calcium Phosphate Bone Graft Substitute
• Collagen Matrix
• Others

Demineralized bone matrix lead the market with around 33.9% of market share in 2024. According to the report, demineralized bone matrix represented the largest market segment. Demineralized bone matrix (DBM) is dominating the bone void fillers market due to its strong osteoinductive properties, which stimulate the differentiation of stem cells into osteoblasts, promoting new bone formation. Furthermore, DBM offers natural bone matrix composition, including collagen and other extracellular matrix proteins, which makes it biocompatible and enables it to integrate seamlessly with the patient's own bone, thus enhancing its efficacy and clinical outcomes. Additionally, the widespread availability of DBM in various forms, such as powders, putties, strips, and sponges for specific clinical scenarios and defect characteristics, is positively influencing the market growth. Apart from this, DBM is easy to handle and exhibits ready-to-use property, which eliminates the need for extensive preparations and processing.

 Analysis by Form:

• Gel and Putty
• Granules
• Others

Gel and putty leads the market in 2024. According to the report, gel and putty represented the largest market segment. Gel and putty hold the majority market share owing to their ease of application during surgical procedures. They offer a malleable consistency, allowing surgeons to mold and shape them to fit the bone defect or void precisely. Furthermore, gel and putty are injectable in nature, which enables minimally invasive procedures, thus minimizing surgical trauma, reducing the risk of complications, and promoting quicker recovery for patients. Apart from this, they provide excellent conformability, which enables them to adapt to the contours of the defect, ensuring complete coverage and contact with the surrounding bone. Additionally, gel and putty bone void fillers are widely used as scaffolds for bone growth and regeneration, as they provide a three-dimensional (3D) matrix that supports the infiltration of new bone cells and blood vessels.

Analysis by Application:

• Spine Fusion
• Bone Fracture
• Others

Bone fracture lead the market with around 45% of the market share in 2024. The report states that the market was dominated by bone fracture. Bone fracture is dominating the market due to increasing accidents, sports injuries, and age-related conditions such as osteoporosis. In this context, bone void fillers are widely used for filling gaps caused by fractures to provide support and promote bone regeneration. Bone void fillers are made from biocompatible materials, such as calcium phosphate-based ceramics, bioactive glasses, and synthetic polymers, which have similar properties to the natural bone and encourage cell attachment and stimulate new bone production. They are also easily available and offer a safe alternative for bone regeneration, thereby reducing surgical complications and improving patient outcomes. Apart from this, the latest developments in bone void fillers to enhance properties, including biocompatibility, osteoinductivity, and mechanical strength, which enables healthcare professionals to select products that suit different bone fracture conditions, are driving the market growth.

Analysis by End User:

• Hospital
• Specialty Clinics
• Others

Hospital leads the market with around 51.2% of market share in 2024. Hospital was the largest market segment, as per the report. Bone void fillers are widely used in hospitals due to the increasing number of surgical procedures associated with orthopedic conditions, sports injuries, and age-related bone disorders. Moreover, hospitals cater to a broad patient population with acute and chronic cases, such as fractures, joint replacements, spinal surgeries, and trauma, which, in turn, is driving the market growth. In addition to this, high availability of the highly skilled and specialized healthcare professional, such as orthopedic surgeons, trauma experts, and orthopedic nurses, for the efficient performing of procedures of bone void fillers is having a positive effect on the market growth. Not only this but also the increase in collaboration of hospitals, companies, and research institutions to conduct clinical trials and provide feedback of new bone void filler products in the market has been supporting market growth.

Regional Analysis:

• North America
  • United States
  • Canada
• Europe
  • Germany
  • France
  • United Kingdom
  • Italy
  • Spain
  • Others
• Asia Pacific
  • China
  • Japan
  • India
  • South Korea
  • Australia
  • Indonesia
  • Others
• Latin America 
  • Brazil
  • Mexico
  • Others
• Middle East and Africa

In 2024, North America accounted for the largest market share of over 39.8%. According to the report, North America represented the largest market segment. North America is dominating the bone void fillers market due to the presence of highly advanced healthcare infrastructure with well-established medical facilities, specialized orthopedic centers, and a strong network of clinical professionals. Furthermore, the rising prevalence of orthopedic conditions in the region due to bone defects, fractures, and age-related injuries is providing an impetus to the market growth. Additionally, the implementation of favorable reimbursement policies by the regional governments to encourage patients to undergo procedures involving bone void fillers is positively influencing the market growth. Moreover, the increasing awareness among the masses and healthcare providers regarding the benefits and applications of bone void fillers is acting as another growth-inducing factor.

Key Regional Takeaways:
 

United States Bone Void Fillers Market Analysis

US accounts for 87% share of the market in North America. The aging population and an increase in the incidence of orthopedic ailments are factors that are driving the market for bone void fillers in the United States. Low bone mass and osteoporosis affect nearly 54 million Americans, according to the data by the Bone Health & Osteoporosis Foundation, thereby increasing the demand for bone graft substitutes like bone void fillers. According to research by the National Institute of Health, over 1.5 million osteoporosis-related fractures occur in the United States each year, and bone void fillers are critical to their healing. Synthetic bone grafts have gained popularity because of the advancements in surgical techniques, especially minimally invasive ones. Another significant factor is sports injuries, of which 8.6 million are reported each year according to research by the National Institute of Health. In addition, the rise in dental surgery and more than 5 million annual dental implants is supporting the application of bone void fillers in oral and maxillofacial treatments. Pet data from the American Dental Association. The market is supported by the presence of big manufacturers like Stryker and Zimmer Biomet, besides the escalating healthcare spending in the region that stood at USD 4.9 Trillion in 2023 according to the data available at Centre for Medicare and Medicaid Services.

Europe Bone Void Fillers Market Analysis

The market for bone void fillers in Europe is being driven by the increased incidence of trauma-related and orthopaedic disorders. About 27 million people in Europe suffer from osteoporosis, and over 4 million fragility fractures are diagnosed each year according to International Osteoporosis Foundation. Also noteworthy is the increasing trend of synthetic bone grafts and advanced biomaterials in the UK, France, and Germany. This growing population in Europe, with more than 20% aged 65 and older, fuels the need for bone void fillers in orthopaedic procedures and fracture restorations. Dental surgery, including two million implant surgeries performed annually in Germany alone, significantly fuels the growth of this industry. Access to surgical procedures using bone void fillers is widespread due to government healthcare programs, such as Germany's statutory health insurance system. The emphasis of Europe on research and innovation is also encouraging new bone grafting techniques, and it is supported by groups like the European Federation of National Associations of Orthopaedics and Traumatology (EFORT).

Asia Pacific Bone Void Fillers Market Analysis

The market for bone void fillers is expanding rapidly in the Asia-Pacific region due to a rise in orthopaedic and dental procedures. Because the population is getting older, Japan and other nations are experiencing higher osteoporosis-related fractures in the population due to the increase in the 65-year old population to 28% according to Population Reference Bureau. As per a recent analysis, the frequency of joint replacement procedures in India has been steadily rising on an annual basis. It is estimated that approximately 200,000 knee replacement surgeries were performed in India in 2020, while hip replacement procedures are projected to experience the fastest growth globally from 2020 to 2026. Surgical operations, especially those involving bone void fillers, have become more accessible with the development of healthcare infrastructure. Industry reports continue to note that by 2030, Asia-Pacific is set to amount for nearly 20% of the healthcare spending around the world. The region has shown one of the fastest growth rates. Demand in the dentistry market is driven by the operations of dental implants, which are also witnessing rapid growth, especially among countries like South Korea and India. Moreover, medical tourism encourages the use of advanced bone graft techniques especially in Thailand and Malaysia. Their cost-effectiveness and biocompatibility are two factors that keep on fueling the growing market for synthetic bone void fillers in this market.

Latin America Bone Void Fillers Market Analysis

In Latin America, the increasing incidence of orthopedic surgeries as well as traumas is an industry driver that propels demand for bone void fillers. Industry data suggests Brazil conducted 1,797,311 orthopaedic procedures total in 2022, continuing to drive a demand for these fillers for bones. Between 30% and 50% of people aged over 50 suffer from osteoporosis, according to National Institutes of Health data. Growth in the adoption of minimally invasive surgical procedures, especially in private hospitals, is improving utilization of bone void fillers. The demand for bone grafting treatments in oral procedures is increased by the expanding dental tourism industry, particularly in Mexico, because over 1 million dental tourists travel there annually. Additionally, government programs, such as SUS in Brazil, target increasing access to healthcare, which fosters the use of advanced medical devices like bone void fillers in all public health facilities.

Middle East and Africa Bone Void Fillers Market Analysis

Growing healthcare spending and the prevalence of orthopaedic disorders are driving the market for bone void fillers in the Middle East and Africa. In a hospital context, the most recent estimate of osteoporosis in Saudi Arabia is 52.8% for women and 63.6% for men, according to statistics from the National Institute of Health. An estimated 4,950 femur fractures per 100,000 people are caused by osteoporosis in Saudi Arabia each year. This is due to the fact that advanced medical facilities are now becoming increasingly accessible in countries such as South Africa and the United Arab Emirates, thus increasing the number of surgical procedures requiring bone void fillers. The scope of bone graft applications in dentistry is also expanding through dental tourism, particularly in the United Arab Emirates, which saw over 691,000 international health tourists visiting Dubai alone in 2023.

Competitive Landscape:

The leading companies in the bone void fillers market are developing new and innovative products, such as biocompatible and osteoconductive materials, that promote bone growth and accelerate the regeneration process. Furthermore, key players are engaged in expanding their portfolio by offering a wide range of bone void fillers that cater to different clinical needs. Additionally, several manufacturers are producing custom and tailor-made products for specific orthopedic procedures, such as spinal fusion, trauma surgery, and joint reconstruction, to establish themselves as market leaders in particular segments. For instance, in 2024, Arthrex launched OrthoPedia Patient, an interactive digital platform offering patients accessible videos on various orthopedic conditions and treatments, enhancing understanding and engagement in their healthcare journey. Moreover, the growing long-term strategic partnerships and collaboration between top companies and research institutions, government agencies, and healthcare facilities to access new technologies and expand their global footprint are strengthening the market growth.

The report provides a comprehensive analysis of the competitive landscape in the bone void fillers market with detailed profiles of all major companies, including:

• Arthrex Inc.
• Bone Support AB
• Collagen Matrix Inc.
• Exactech Inc.
• Medical Device Business Services Inc.
• Medtronic plc
• NuVasive Inc.
• Stryker Corporation
• Zimmer Biomet

Latest News and Developments:

• Aug 2024: Arthrex Inc. and Graftys announced the renewal of their multi-year supply agreement for advanced synthetic bone graft materials.
• June 2024: MCRA LLC. announced its role in supporting Bone Support AB in the development of an implantable device/drug combination bone void filler that provides a single-stage approach for managing bone infection.
• July 2021: Exactech Inc. entered into a strategic partnership with RTI Surgical to develop and supply biologic bone substitutes.

Bone Void Fillers Market Report Scope:

Key Benefits for Stakeholders:

• IMARC’s report offers a comprehensive quantitative analysis of various market segments, historical and current market trends, market forecasts, and dynamics of the bone void fillers market from 2025-2033.
• The research study provides the latest information on the market drivers, challenges, and opportunities in the global bone void fillers market.
• The study maps the leading, as well as the fastest-growing, regional markets. It further enables stakeholders to identify the key country-level markets within each region.
• Porter's Five Forces analysis assists stakeholders in assessing the impact of new entrants, competitive rivalry, supplier power, buyer power, and the threat of substitution. It helps stakeholders to analyze the level of competition within the bone void fillers industry and its attractiveness.
• Competitive landscape allows stakeholders to understand their competitive environment and provides an insight into the current positions of key players in the market.