Alpha 1 Antitrypsin Deficiency Treatment Market Report by Treatment Type (Augmentation Therapy, Bronchodilators, Corticosteroids, Oxygen Therapy, and Others), Route of Administration (Parenteral, Inhalation, Oral), End User (Hospitals, Specialty Clinics, and Others), and Region 2025-2033

Alpha 1 Antitrypsin Deficiency Treatment Market Report by Treatment Type (Augmentation Therapy, Bronchodilators, Corticosteroids, Oxygen Therapy, and Others), Route of Administration (Parenteral, Inhalation, Oral), End User (Hospitals, Specialty Clinics, and Others), and Region 2025-2033

Report Format: PDF+Excel | Report ID: SR112025A2467

Market Overview:

The global alpha 1 antitrypsin deficiency treatment market size reached USD 2.2 Billion in 2024. Looking forward, IMARC Group expects the market to reach USD 4.2 Billion by 2033, exhibiting a growth rate (CAGR) of 7.22% during 2025-2033.

Report Attribute
Key Statistics
Base Year
2024
Forecast Years
2025-2033
Historical Years
2019-2024
Market Size in 2024 USD 2.2 Billion
Market Forecast in 2033 USD 4.2 Billion
Market Growth Rate (2025-2033) 7.22%


Alpha-1 antitrypsin (AAT) deficiency refers to a genetic disorder due to which the body does not produce sufficient AAT protein. AAT protein is essential for protecting the lungs and liver from the adverse effects of other proteins in the body. Patients with severe AAT deficiency may develop liver cirrhosis, chronic obstructive pulmonary diseases (COPD) and emphysema diseases. It can be diagnosed through a genetic or a blood test. Some of the treatment methods include augmentation therapy, pulmonary rehabilitation and oxygen therapy that use medicines, such as bronchodilators and corticosteroids, which can be injected intravenously or inhaled.

The increasing prevalence of respiratory disorders is one of the key factors driving the growth of the market. Furthermore, widespread adoption of augmentation therapy is providing a thrust to the market growth. This therapy involves extracting AAT protein from a healthy donor’s blood plasma for increasing AAT levels in the respiratory tract of patients. In line with this, this treatment also delays the progression of emphysema, minimizes the frequency of exacerbations and improves recovery speed, which, in turn, is contributing to its increasing preference among both the patients and healthcare providers. Additionally, various technological advancements in the diagnostic methods and the development of innovative processes for the production and purification of AAT are acting as other growth-inducing factors. They have improved quality and are free from contaminants, such as viruses and bacteria. Other factors, including extensive research and development (R&D) activities, along with improvements in medical infrastructure, are anticipated to drive the market further. 

Key Market Segmentation:

IMARC Group provides an analysis of the key trends in each sub-segment of the global alpha 1 antitrypsin deficiency treatment market report, along with forecasts at the global, regional and country level from 2025-2033. Our report has categorized the market based on treatment type, route of administration and end user.

Breakup by Treatment Type:

  • Augmentation Therapy
  • Bronchodilators
  • Corticosteroids
  • Oxygen Therapy
  • Others
     

Breakup by Route of Administration:

  • Parenteral
  • Inhalation
  • Oral
     

Breakup by End User:

  • Hospitals
  • Specialty Clinics
  • Others
     

Breakup by Region:

  • North America
    • United States
    • Canada
  • Asia Pacific
    • China
    • Japan
    • India
    • South Korea
    • Australia
    • Indonesia
    • Others
  • Europe
    • Germany
    • France
    • United Kingdom
    • Italy
    • Spain
    • Russia
    • Others
  • Latin America
    • Brazil
    • Mexico
    • Others
  • Middle East and Africa
     

Competitive Landscape:

The competitive landscape of the industry has also been examined with some of the key players being AstraZeneca PLC, C.H. Boehringer Sohn AG & Ko. KG, CSL Limited, GlaxoSmithKline Plc, Grifols S.A., Kamada Ltd., LFB Biomedicaments S.A., Pfizer Inc., Takeda Pharmaceutical Company Limited and Teva Pharmaceutical Industries Ltd.

Report Coverage:

Report Features Details
Base Year of the Analysis 2024
Historical Period 2019-2024
Forecast Period 2025-2033
Units Billion USD
Segment Coverage Treatment Type, Route of Administration, End User, Region
Region Covered Asia Pacific, Europe, North America, Latin America, Middle East and Africa
Countries Covered United States, Canada, Germany, France, United Kingdom, Italy, Spain, Russia, China, Japan, India, South Korea, Australia, Indonesia, Brazil, Mexico
Companies Covered AstraZeneca PLC, C.H. Boehringer Sohn AG & Ko. KG, CSL Limited, GlaxoSmithKline Plc, Grifols S.A., Kamada Ltd., LFB Biomedicaments S.A., Pfizer Inc., Takeda Pharmaceutical Company Limited and Teva Pharmaceutical Industries Ltd.
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Delivery Format PDF and Excel through Email (We can also provide the editable version of the report in PPT/Word format on special request)

Key Questions Answered in This Report

The alpha 1 antitrypsin deficiency treatment market was valued at USD 2.2 Billion in 2024.

IMARC estimates the alpha 1 antitrypsin deficiency treatment market to exhibit a CAGR of 7.22% during 2025-2033.

The growing awareness about alpha-1 antitrypsin deficiency (AATD), advancements in genetic testing and diagnosis, increasing prevalence of AATD-related diseases, development of innovative therapies and treatments, and expanding healthcare access and government support for rare diseases are the primary factors driving the alpha 1 antitrypsin deficiency treatment market.

On a regional level, the market has been classified into North America, Asia Pacific, Europe, Latin America, and Middle East and Africa, wherein North America currently dominates the market.

Some of the major players in the alpha 1 antitrypsin deficiency treatment market include AstraZeneca PLC, C.H. Boehringer Sohn AG & Ko. KG, CSL Limited, GlaxoSmithKline Plc, Grifols S.A., Kamada Ltd., LFB Biomedicaments S.A., Pfizer Inc., Takeda Pharmaceutical Company Limited and Teva Pharmaceutical Industries Ltd., etc.

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Alpha 1 Antitrypsin Deficiency Treatment Market Report by Treatment Type (Augmentation Therapy, Bronchodilators, Corticosteroids, Oxygen Therapy, and Others), Route of Administration (Parenteral, Inhalation, Oral), End User (Hospitals, Specialty Clinics, and Others), and Region 2025-2033
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