Hereditary Angioedema Market Size to Reach US$ 3.5 Billion by 2034, Impelled by Advancements in Early Detection

November 22, 2024 | Healthcare


Hereditary Angioedema Market Outlook 2024-2034:

The hereditary angioedema market size reached a value of US$ 1.8 Billion in 2023. Looking forward, the market is expected to reach US$ 3.5 Billion by 2034, exhibiting a growth rate (CAGR) of 6.1% during 2024-2034. The market is driven by the plasma-derived C1 esterase inhibitor (Human) therapy indicated for the treatment of hereditary angioedema attacks in adult and pediatric patients. Additionally, the development of targeted therapies and innovative treatments is further propelling the market growth.

Hereditary Angioedema Market

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Advances in Early Detection and Diagnostic Technologies: Driving the Hereditary Angioedema Market 

The hereditary angioedema (HAE) market is experiencing rapid growth, driven by significant advancements in early detection and diagnostic technologies. Historically, diagnosing HAE has been challenging due to its overlapping symptoms with other conditions, often leading to delayed or misdiagnoses. However, the emergence of innovative diagnostic tools is revolutionizing patient outcomes and reshaping the market. Moreover, next-generation sequencing (NGS) and advanced genetic testing have been pivotal in improving HAE diagnosis. These technologies allow for the precise identification of genetic mutations in genes such as SERPING1, F12, or PLG, which are associated with different HAE types. Additionally, biomarker-based diagnostic assays are providing clinicians with reliable indicators to detect HAE earlier and more accurately. Point-of-care diagnostic kits are another breakthrough, offering rapid results and supporting immediate clinical decision-making. In line with this, machine learning (ML) is being applied to analyze complex datasets, enabling healthcare providers to predict attack patterns and optimize personalized treatment regimens. Telemedicine has also enhanced access to specialized diagnostics, particularly in remote and underserved areas, allowing for virtual consultations and facilitating genetic testing without the need for physical visits. As diagnostic technologies advance, pharmaceutical companies are expanding their portfolios of targeted therapies, further driving market growth. The integration of cutting-edge diagnostics is thus pivotal in advancing HAE care, enhancing patient outcomes, and fueling the continued expansion of the hereditary angioedema market.

Development of Novel Therapies and Pharmacological Treatments: Contributing to Market Expansion

The hereditary angioedema market is expanding rapidly, driven by the development of novel therapies and pharmacological treatments. Recent advancements in drug development are transforming the treatment landscape, providing new opportunities for effective management and prevention of HAE attacks. Innovative therapies such as C1-inhibitor replacement treatments have significantly improved the ability to prevent and treat acute attacks by addressing the underlying protein deficiency. These therapies, available in intravenous and subcutaneous formulations, have set new standards in HAE care. Moreover, the introduction of bradykinin B2 receptor antagonists and kallikrein inhibitors has provided targeted approaches to interrupt the pathways responsible for swelling, offering more tailored solutions for patients. Oral therapies represent another groundbreaking advancement, providing non-invasive options that enhance patient convenience and adherence. These small molecule drugs inhibit key enzymes in the HAE pathway, reducing the frequency and severity of attacks. The ease of oral administration has the potential to improve the quality of life for HAE patients, reducing the need for frequent injections or infusions. Furthermore, gene therapy is bolstering market growth by offering a long-term or even curative approach with the potential to correct the genetic mutations responsible for HAE. Ongoing clinical trials are exploring new therapeutic targets and delivery methods, ensuring a robust pipeline for future treatments. These developments are expanding the HAE market by improving patient outcomes, increasing disease awareness, and boosting demand for innovative treatments.

Regional Analysis:

The major markets for hereditary angioedema include the United States, Germany, France, the United Kingdom, Italy, Spain, and Japan. According to projections by IMARC, the United States has the largest patient pool for hereditary angioedema while also representing the biggest market for its treatment. This can be attributed to the increasing usage of innovative therapies such as C1-inhibitor replacement treatments that have significantly improved the ability to prevent and treat acute attacks by addressing the underlying protein deficiency.

Moreover, the introduction of bradykinin B2 receptor antagonists and kallikrein inhibitors has provided targeted approaches to interrupt the pathways responsible for swelling, offering more tailored solutions for patients.

Besides this, gene therapy is a promising area of research, with the potential to correct the genetic mutations responsible for HAE, offering a long-term or even curative approach. Additionally, ongoing clinical trials are exploring new therapeutic targets and delivery methods, ensuring a robust pipeline for future treatments​.

Key information covered in the report.

  • Base Year: 2023
  • Historical Period: 2018-2023
  • Market Forecast: 2024-2034
     

Countries Covered

  • United States
  • Germany
  • France
  • United Kingdom
  • Italy
  • Spain
  • Japan
     

 Analysis Covered Across Each Country

  • Historical, current, and future epidemiology scenario
  • Historical, current, and future performance of the hereditary angioedema market
  • Historical, current, and future performance of various therapeutic categories in the market
  • Sales of various drugs across the hereditary angioedema market
  • Reimbursement scenario in the market
  • In-market and pipeline drugs
     

Competitive Landscape:

This report offers a comprehensive analysis of current hereditary angioedema marketed drugs and late-stage pipeline drugs.

In-Market Drugs

  • Drug Overview
  • Mechanism of Action
  • Regulatory Status
  • Clinical Trial Results
  • Drug Uptake and Market Performance
     

 Late-Stage Pipeline Drugs

  • Drug Overview
  • Mechanism of Action
  • Regulatory Status
  • Clinical Trial Results
  • Drug Uptake and Market Performance
     

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Hereditary Angioedema Market Size to Reach US$ 3.5 Billion by 2034, Impelled by Advancements in Early Detection
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